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Article

Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster.

The Journal of pharmacology and experimental therapeutics - 1 Jan 2002

Pendleton Robert G, Parvez Feroz, Sayed Marwa, Hillman Ralph

Abstract excerpt

The human gene that codes for the protein alpha-synuclein has been transferred into the Drosophila melanogaster genome. The transgenic flies recapitulate some of the essential features of Parkinson's disease. These include the degeneration of certain dopaminergic neurons in the brain accompanied by the appearance of age-dependent abnormalities in locomotor activity. In the present study, we tested the locomotor...

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PMID: 11752102
DOI: 10.1124/jpet.300.1.91

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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