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Article

TRIM21 controls Toll-like receptor 2 responses in bone-marrow-derived macrophages.

Immunology - 1 Mar 2020

Sjöstrand Maria, Carow Berit, Nyberg William A, Covacu Ruxandra, Rottenberg Martin E, Espinosa Alexander

Abstract excerpt

TRIM21 is an interferon-stimulated E3 ligase that controls the activity of pattern-recognition signaling via ubiquitination of interferon regulatory factors and DDX41. Previous studies on the role of TRIM21 in innate immune responses have yielded contradictory results, suggesting that the role of TRIM21 is cell specific. Here, we report that bone-marrow-derived macrophages (BMDMs) generated from Trim21-/- mice...

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Identifiers

PMID: 31755557
DOI: 10.1111/imm.13157
PMCID: PMC7011629

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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