Article
Heritability of antibody isotype and subclass responses to Plasmodium falciparum antigens.
PloS one - 8 Oct 2009
Duah Nancy O, Weiss Helen A, Jepson Annette, Tetteh Kevin K A, Whittle Hilton C, Conway David J
Abstract excerpt
BACKGROUND: It is important to understand the extent to which genetic factors regulate acquired immunity to common infections. A classical twin study design is useful to estimate the heritable component of variation in measurable immune parameters. METHODOLOGY/PRINCIPAL FINDINGS: This study assessed the relative heritability of different plasma antibody isotypes and subclasses (IgG1, IgG2, IgG3, IgG4, IgM, IgA...
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