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Article

Genetic and functional analysis of the DLG4 gene encoding the post-synaptic density protein 95 in schizophrenia.

PloS one - 2 Dec 2010

Cheng Min-Chih, Lu Chao-Lin, Luu Sy-Ueng, Tsai Ho-Min, Hsu Shih-Hsin, Chen Tzu-Ting, Chen Chia-Hsiang

Abstract excerpt

Hypofunction of N-methyl-D-aspartate (NMDA) receptor-mediated signal transduction has been implicated in the pathophysiology of schizophrenia. Post-synaptic density protein 95 (PSD95) plays a critical role in regulating the trafficking and activity of the NMDA receptor and altered expression of the PSD95 has been detected in the post-mortem brain of patients with schizophrenia. The study aimed to examine whether...

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Identifiers

PMID: 21151988
DOI: 10.1371/journal.pone.0015107
PMCID: PMC2996301

Genes

DLG4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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