Article
Resequencing and Association Analysis of Six PSD-95-Related Genes as Possible Susceptibility Genes for Schizophrenia and Autism Spectrum Disorders.
Scientific reports - 7 Jun 2016
Xing Jingrui, Kimura Hiroki, Wang Chenyao, Ishizuka Kanako, Kushima Itaru, Arioka Yuko, Yoshimi Akira, Nakamura Yukako, Shiino Tomoko, Oya-Ito Tomoko, Takasaki Yuto, Uno Yota, Okada Takashi, Iidaka Tetsuya, Aleksic Branko, Mori Daisuke, Ozaki Norio
Abstract excerpt
PSD-95 associated PSD proteins play a critical role in regulating the density and activity of glutamate receptors. Numerous previous studies have shown an association between the genes that encode these proteins and schizophrenia (SZ) and autism spectrum disorders (ASD), which share a substantial portion of genetic risks. We sequenced the protein-encoding regions of DLG1, DLG2, DLG4, DLGAP1, DLGAP2, and SynGAP in...
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