Article
Neuroprotective effect of chondroitin sulfate on SH‑SY5Y cells overexpressing wild‑type or A53T mutant α‑synuclein.
Molecular medicine reports - 1 Dec 2017
Ju Chuanxia, Gao Jianjun, Hou Lin, Wang Lei, Zhang Fang, Sun Fusheng, Zhang Tingting, Xu Pingping, Shi Zhenyan, Hu Fang, Zhang Congxiao
Abstract excerpt
Accumulation of α‑synuclein (α‑SYN) is a common pathology for Parkinson's disease (PD). There is abundant evidence that the toxic‑gain‑of‑function of α‑SYN's is associated with aggregation and consequent effects. To assess the potential of chondroitin sulfate (CS) in this regard, the present study investigated its neuroprotective on SH‑SY5Y cells overexpressing wild‑type (WT) or A53T mutant α‑SYN. Cell viability...
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