Article
In vitro cytochrome p450 activity decreases in children with high pediatric end-stage liver disease scores.
Drug metabolism and disposition: the biological fate of chemicals - 1 Feb 2013
De Bock Lies, Boussery Koen, Van Winckel Myriam, De Paepe Peter, Rogiers Xavier, Stephenne Xavier, Sokal Etienne, Van Bocxlaer Jan
Abstract excerpt
To improve the modeling and simulation of pharmacokinetics in pediatric patients, research into developmental and disease-specific determinants is needed. This article describes the evaluation of the activity of in vitro cytochrome P450 (P450), an important enzyme family in drug metabolism, in children with hepatic dysfunction. The activity of six P450 isoforms (CYP1A2, 2C9, 2C19, 2D6, 2E1, and 3A4) was evaluated...
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