Article
ARHGAP18 is a novel gene under positive natural selection that influences HbF levels in β-thalassaemia.
Molecular genetics and genomics : MGG - 1 Feb 2018
He Yunyan, Luo Jianming, Chen Yang, Zhou Xiaoheng, Yu Shanjuan, Jin Ling, Xiao Xuan, Jia Siyuan, Liu Qiang
Abstract excerpt
Foetal haemoglobin (HbF) plays a dominant role in ameliorating the morbidity and mortality of β-thalassaemia. A better understanding of the loci and genes involved in HbF expression would be beneficial for the treatment of β-thalassaemia major. However, the genes associated with HbF expression remain largely unknown. In this study, we first explored large-scale data sets and examined the human genome for evidence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.