Article
Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis.
Molecular brain - 5 Oct 2017
Yoshioka Nozomu, Miyata Shinji, Tamada Atsushi, Watanabe Yumi, Kawasaki Asami, Kitagawa Hiroshi, Takao Keizo, Miyakawa Tsuyoshi, Takeuchi Kosei, Igarashi Michihiro
Abstract excerpt
Chondroitin sulfate (CS) is an important glycosaminoglycan and is mainly found in the extracellular matrix as CS proteoglycans. In the brain, CS proteoglycans are highly concentrated in perineuronal nets (PNNs), which surround synapses and modulate their functions. To investigate the importance of CS, we produced and precisely examined mice that were deficient in the CS synthesizing enzyme, CSGalNAcT1 (T1KO)....
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