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Article

Cigarette smoke activates CFTR through ROS-stimulated cAMP signaling in human bronchial epithelial cells.

American journal of physiology. Cell physiology - 1 Jan 2018

Wong Francis H, AbuArish Asmahan, Matthes Elizabeth, Turner Mark J, Greene Lana E, Cloutier Alexandre, Robert Renaud, Thomas David Y, Cosa Gonzalo, Cantin André M, Hanrahan John W

Abstract excerpt

Air pollution stimulates airway epithelial secretion through a cholinergic reflex that is unaffected in cystic fibrosis (CF), yet a strong correlation is observed between passive smoke exposure in the home and impaired lung function in CF children. Our aim was to study the effects of low smoke concentrations on cystic fibrosis transmembrane conductance regulator (CFTR) function in vitro. Cigarette smoke extract...

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Source

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Identifiers

PMID: 28978522
DOI: 10.1152/ajpcell.00099.2017
PMCID: PMC5866379

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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