Article
Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers.
American journal of respiratory and critical care medicine - 15 May 2006
Cantin André M, Hanrahan John W, Bilodeau Ginette, Ellis Lynda, Dupuis Annie, Liao Jie, Zielenski Julian, Durie Peter
Abstract excerpt
RATIONALE: Cigarette smoke extract inhibits chloride secretion in human bronchial epithelial cells. Oxidants decrease gene expression, protein expression, and function of the cystic fibrosis transmembrane conductance regulator (CFTR). OBJECTIVES: Because cigarette smoke is a rich source of oxidants, we verified the hypothesis that CFTR may be suppressed by exposure to cigarette smoke in vitro and in vivo....
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