Article
An oocyte-specific methylation imprint center in the mouse U2afbp-rs/U2af1-rs1 gene marks the establishment of allele-specific methylation during preimplantation development.
Genomics - 1 Sept 1997
Shibata H, Ueda T, Kamiya M, Yoshiki A, Kusakabe M, Plass C, Held W A, Sunahara S, Katsuki M, Muramatsu M, Hayashizaki Y
Abstract excerpt
An oocyte-specific methylation imprint mark region, consisting of approximately 200 bp from the mouse imprinted gene U2afbp-rs, was identified within an area containing a CpG island and a short tandem repeat sequence. The oocyte-specific methylation was preserved in fertilized eggs and then expanded on the repressed maternal allele during preimplantation development until the adult methylation pattern was...
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