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Article

Malignant Phenotypes in Metastatic Melanoma are Governed by SR-BI and its Association with Glycosylation and STAT5 Activation.

Molecular cancer research : MCR - 1 Jan 2018

Kinslechner Katharina, Schörghofer David, Schütz Birgit, Vallianou Maria, Wingelhofer Bettina, Mikulits Wolfgang, Röhrl Clemens, Hengstschläger Markus, Moriggl Richard, Stangl Herbert, Mikula Mario

Abstract excerpt

Metastatic melanoma is hallmarked by elevated glycolytic flux and alterations in cholesterol homeostasis. The contribution of cholesterol transporting receptors for the maintenance of a migratory and invasive phenotype is not well defined. Here, the scavenger receptor class B type I (SCARB1/SR-BI), a high-density lipoprotein (HDL) receptor, was identified as an estimator of melanoma progression in patients. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28974560
DOI: 10.1158/1541-7786.MCR-17-0292
PMCID: PMC5751895

Genes

SCARB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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