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Article

Polymorphisms in the Pfcrt, Pfmdr1, and Pfk13 genes of Plasmodium falciparum isolates from southern Brazzaville, Republic of Congo.

Scientific reports - 14 Nov 2024

Baina Marcel Tapsou, Djontu Jean Claude, Mbama Ntabi Jacques Dollon, Mfoutou Mapanguy Claujens Chastel, Lissom Abel, Vouvoungui Christevy Jeannhey, Boumpoutou Reauchelvy Kamal, Mouanga Alain Maxime, Nguimbi Etienne, Ntoumi Francine

Abstract excerpt

This study aimed to analyze polymorphisms in Pfcrt, Pfmdr1, and Pfk13 genes' markers of resistance to Artemisinin-based combination therapy (ACT), in Plasmodium falciparum isolates from southern Brazzaville, 15 years after the adoption of ACT in the Republic of Congo. A total of 369 microscopy-confirmed malaria-infected individuals were enrolled from March to October 2021 in the community and in health facilities...

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Identifiers

PMID: 39543235
DOI: 10.1038/s41598-024-78670-2
PMCID: PMC11564878

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