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Detection of known and novel ALK fusion transcripts in lung cancer patients using next-generation sequencing approaches

26 Sept 2017

Abstract excerpt

Abstract Rearrangements of the anaplastic lymphoma kinase (ALK) gene in non-small cell lung cancer (NSCLC) represent a novel molecular target in a small subset of tumors. Although ALK rearrangements are usually assessed by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), molecular approaches have recently emerged as relevant alternatives in routine laboratories. Here, we evaluated the use...

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PMID: 28970558
DOI: 10.1038/s41598-017-12679-8

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