Article
Development, testing and validation of a targeted NGS-panel for the detection of actionable mutations in lung cancer (NSCLC) using anchored multiplex PCR technology in a multicentric setting.
Pathology oncology research : POR - 1 Jan 2024
Kumbrink Jörg, Demes Melanie-Christin, Jeroch Jan, Bräuninger Andreas, Hartung Kristin, Gerstenmaier Uwe, Marienfeld Ralf, Hillmer Axel, Bohn Nadine, Lehning Christina, Ferch Ferdinand, Wild Peter, Gattenlöhner Stefan, Möller Peter, Klauschen Frederick, Jung Andreas
Abstract excerpt
Lung cancer is a paradigm for a genetically driven tumor. A variety of drugs were developed targeting specific biomarkers requiring testing for tumor genetic alterations in relevant biomarkers. Different next-generation sequencing technologies are available for library generation: 1) anchored multiplex-, 2) amplicon based- and 3) hybrid capture-based-PCR. Anchored multiplex PCR-based sequencing was investigated...
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