Article
Characterization of Trypanosoma cruzi MutY DNA glycosylase ortholog and its role in oxidative stress response.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Nov 2017
Kunrath-Lima Marianna, Repolês Bruno Marçal, Alves Ceres Luciana, Furtado Carolina, Rajão Matheus Andrade, Macedo Andrea Mara, Franco Glória Regina, Pena Sérgio Danilo Junho, Valenzuela Lucía, Wisnovsky Simon, Kelley Shana O, Galanti Norbel, Cabrera Gonzalo, Machado Carlos Renato
Abstract excerpt
Trypanosoma cruzi is a protozoan parasite and the causative agent of Chagas disease. Like most living organisms, it is susceptible to oxidative stress, and must adapt to distinct environments. Hence, DNA repair is essential for its survival and the persistence of infection. Therefore, we studied whether T. cruzi has a homolog counterpart of the MutY enzyme (TcMYH), important in the DNA Base Excision Repair (BER)...
Topics
- Amino Acid Sequence
- DNA Damage
- DNA Glycosylases
- DNA Repair
- DNA, Mitochondrial
- Enzyme Activation
- Glucose Oxidase
- Hydrogen Peroxide