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Article

Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair.

Journal of molecular biology - 17 Sept 2004

Peña-Diaz Javier, Akbari Mansour, Sundheim Ottar, Farez-Vidal M Esther, Andersen Sonja, Sneve Ragnhild, Gonzalez-Pacanowska Dolores, Krokan Hans E, Slupphaug Geir

Abstract excerpt

Enzymes involved in genomic maintenance of human parasites are attractive targets for parasite-specific drugs. The parasitic protozoan Trypanosoma cruzi contains at least two enzymes involved in the protection against potentially mutagenic uracil, a deoxyuridine triphosphate nucleotidohydrolase (dUTPase) and a uracil-DNA glycosylase belonging to the highly conserved UNG-family. Uracil-DNA glycosylase activities...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15342237
DOI: 10.1016/j.jmb.2004.07.043

Genes

UNG
MBD4
TDG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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