Article
Understanding pneumococcal serotype 1 biology through population genomic analysis.
BMC infectious diseases - 8 Nov 2016
Chaguza Chrispin, Cornick Jennifer E, Harris Simon R, Andam Cheryl P, Bricio-Moreno Laura, Yang Marie, Yalcin Feyruz, Ousmane Sani, Govindpersad Shanil, Senghore Madikay, Ebruke Chinelo, Du Plessis Mignon, Kiran Anmol M, Pluschke Gerd, Sigauque Betuel, McGee Lesley, Klugman Keith P, Turner Paul, Corander Jukka, Parkhill Julian, Collard Jean-Marc, Antonio Martin, von Gottberg Anne, Heyderman Robert S, French Neil, Kadioglu Aras, Hanage William P, Everett Dean B, Bentley Stephen D
Abstract excerpt
BACKGROUND: Pneumococcus kills over one million children annually and over 90 % of these deaths occur in low-income countries especially in Sub-Saharan Africa (SSA) where HIV exacerbates the disease burden. In SSA, serotype 1 pneumococci particularly the endemic ST217 clone, causes majority of the pneumococcal disease burden. To understand the evolution of the virulent ST217 clone, we analysed ST217 whole genomes...
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