Article
Sequence type 1 group B Streptococcus, an emerging cause of invasive disease in adults, evolves by small genetic changes.
Proceedings of the National Academy of Sciences of the United States of America - 19 May 2015
Flores Anthony R, Galloway-Peña Jessica, Sahasrabhojane Pranoti, Saldaña Miguel, Yao Hui, Su Xiaoping, Ajami Nadim J, Holder Michael E, Petrosino Joseph F, Thompson Erika, Margarit Y Ros Immaculada, Rosini Roberto, Grandi Guido, Horstmann Nicola, Teatero Sarah, McGeer Allison, Fittipaldi Nahuel, Rappuoli Rino, Baker Carol J, Shelburne Samuel A
Abstract excerpt
The molecular mechanisms underlying pathogen emergence in humans is a critical but poorly understood area of microbiologic investigation. Serotype V group B Streptococcus (GBS) was first isolated from humans in 1975, and rates of invasive serotype V GBS disease significantly increased starting in the early 1990s. We found that 210 of 229 serotype V GBS strains (92%) isolated from the bloodstream of nonpregnant...
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