Article
Population-based studies of myocardial hypertrophy: high resolution cardiovascular magnetic resonance atlases improve statistical power.
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance - 3 Feb 2014
de Marvao Antonio, Dawes Timothy J W, Shi Wenzhe, Minas Christopher, Keenan Niall G, Diamond Tamara, Durighel Giuliana, Montana Giovanni, Rueckert Daniel, Cook Stuart A, O'Regan Declan P
Abstract excerpt
BACKGROUND: Cardiac phenotypes, such as left ventricular (LV) mass, demonstrate high heritability although most genes associated with these complex traits remain unidentified. Genome-wide association studies (GWAS) have relied on conventional 2D cardiovascular magnetic resonance (CMR) as the gold-standard for phenotyping. However this technique is insensitive to the regional variations in wall thickness which are...
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