Article
Deep-learning analysis of 3D microarchitectural remodeling in hypertrophic cardiomyopathy.
Science (New York, N.Y.) - 15 Jan 2026
Wei Eric Q, Beyer Martin, Brown Kemar J, Bansbach Alexander J, Gorham Joshua M, McDonough Barbara, Chen Huachen, Khoramjoo Mobin, Zhang Anran, Bishop Brian, Ahmad Ferhaan, Del Rio Carlos, Chang Ching-Pin, Ryba David M, Day Sharlene M, Fatkin Diane, Oudit Gavin Y, Seidman Christine E, Seidman Jonathan G
Abstract excerpt
Hypertrophic cardiomyopathy (HCM), a genetic heart disease defined by unexplained cardiac wall thickening, is a leading cause of sudden death worldwide. However, the three-dimensional organization of cardiac tissue underlying left ventricular hypertrophy remains poorly understood. We developed CaMVIA-3D, a deep-learning volumetric imaging and analysis pipeline to characterize cardiac microarchitecture. Analysis...
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