Article
ND10 protein PML is recruited to herpes simplex virus type 1 prereplicative sites and replication compartments in the presence of viral DNA polymerase.
Journal of virology - 1 Dec 1998
Burkham J, Coen D M, Weller S K
Abstract excerpt
Herpes simplex virus type 1 (HSV-1) infection results in the disruption of ND10 (also called nuclear bodies, PODs, or PML-associated bodies), which are nuclear matrix domains of unknown function present in mammalian cells. After ND10 disruption, viral transcription and DNA replication occur in gl...
Topics
- Cell Compartmentation
- Cell Line
- DNA, Viral
- DNA-Binding Proteins
- DNA-Directed DNA Polymerase
- Herpesvirus 1, Human
- Humans
- Microscopy, Fluorescence
- Models, Biological
- Mutation
- Neoplasm Proteins
- Nuclear Matrix
- Nuclear Proteins
- Promyelocytic Leukemia Protein
- Time Factors
- Transcription Factors
- Tumor Suppressor Proteins
- Viral Proteins