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Article

Uncommon somatic mutations in metastatic NUT midline carcinoma.

Tumori - 15 Nov 2017

Cavalieri Stefano, Stathis Anastasios, Fabbri Alessandra, Sonzogni Angelica, Perrone Federica, Tamborini Elena, Pelosi Giuseppe, de Braud Filippo, Platania Marco

Abstract excerpt

INTRODUCTION:: NUT midline carcinoma (NMC) is a rare and aggressive epithelial cancer arising from median organs. It is driven by chromosomal translocation t(15;19) involving the rearrangement of NUT (nuclear protein in testis) and BRD4 (bromodomain 4) genes leading to fusion oncoprotein BRD4-NUT. CASE PRESENTATION:: We report the case of a woman who was previously treated with induction chemotherapy, surgery,...

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Source

Identifiers

PMID: 28967088
DOI: 10.5301/tj.5000685

Genes

BRD4
DCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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