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Article

DNA methylation-based classification of sinonasal tumors

28 Nov 2022

Abstract excerpt

The diagnosis of sinonasal tumors is challenging due to a heterogeneous spectrum of various differential diagnoses as well as poorly defined, disputed entities such as sinonasal undifferentiated carcinomas (SNUCs). In this study, we apply a machine learning algorithm based on DNA methylation patterns to classify sinonasal tumors with clinical-grade reliability. We further show that sinonasal tumors with SNUC...

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PMID: 36443295
DOI: 10.1038/s41467-022-34815-3

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