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Article

In silico identification of rescue sites by double force scanning.

Bioinformatics (Oxford, England) - 15 Jan 2018

Tiberti Matteo, Pandini Alessandro, Fraternali Franca, Fornili Arianna

Abstract excerpt

Motivation: A deleterious amino acid change in a protein can be compensated by a second-site rescue mutation. These compensatory mechanisms can be mimicked by drugs. In particular, the location of rescue mutations can be used to identify protein regions that can be targeted by small molecules to reactivate a damaged mutant. Results: We present the first general computational method to detect rescue sites. By...

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Identifiers

PMID: 28961796
DOI: 10.1093/bioinformatics/btx515
PMCID: PMC5860198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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