Article
The rs10781468 Genetic Polymorphism of the Gαq (GNAQ) Gene Is Associated With Responsiveness to Opioid Analgesics in Patients With Postoperative and Cancer Pain: An Exploratory Study.
Neuropsychopharmacology reports - 1 Sept 2026
Owada Hiroaki, Nishizawa Daisuke, Mieda Tsutomu, Tsujita Miki, Nakagawa Hideyuki, Yamaguchi Shigeki, Tsuchida Rikuhei, Yokoshima Yaeko, Kitamura Akira, Hayashida Masakazu, Fukuda Ken-Ichi, Ichinohe Tatsuya, Ikeda Kazutaka, Kurano Makoto, Sumitani Masahiko, Uchida Kanji
Abstract excerpt
BACKGROUND: G protein-coupled receptors, the largest class of cell surface receptors, are ubiquitously expressed throughout the body. Different subtypes of G protein α subunits activate distinct intracellular signaling pathways and mediate opioid analgesic effects. However, the contributions of these Gα subunits remain unclear. We conducted a hypothesis-generating, two-stage candidate gene association study to...
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