Article
Assessing molecular initiating events (MIEs), key events (KEs) and modulating factors (MFs) for styrene responses in mouse lungs using whole genome gene expression profiling following 1-day and multi-week exposures.
Toxicology and applied pharmacology - 15 Nov 2017
Andersen Melvin E, Cruzan George, Black Michael B, Pendse Salil N, Dodd Darol, Bus James S, Sarang Satinder S, Banton Marcy I, Waites Robbie, McMullen Patrick D
Abstract excerpt
Styrene increased lung tumors in mice at chronic inhalation exposures of 20ppm and greater. MIEs, KEs and MFs were examined using gene expression in three strains of male mice (the parental C57BL/6 strain, a CYP2F2(-/-) knock out and a CYP2F2(-/-) transgenic containing human CYP2F1, 2A13 and 2B6). Exposures were for 1-day and 1, 4 and 26weeks. After 1-day exposures at 1, 5, 10, 20, 40 and 120ppm significant...
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