Article
Molecular genetics of Alzheimer's disease: an update.
Annals of medicine - 1 Jan 2008
Brouwers Nathalie, Sleegers Kristel, Van Broeckhoven Christine
Abstract excerpt
Alzheimer's disease (AD) is a complex disorder of the central nervous system (CNS). Molecular genetic research has provided a wealth of information regarding the genetic etiology of this devastating disease. Identification and functional characterization of autosomal dominant mutations in the amyloid precursor protein gene (APP) and the presenilin genes 1 and 2 (PSEN1 and PSEN2) have contributed substantially to...
Topics
- Alleles
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Animals
- Apolipoprotein E4
- Genetic Predisposition to Disease
- Humans
- Mutation
- Polymorphism, Single Nucleotide
- Presenilin-1
- Presenilin-2