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Article

Interleukin 1α Is Critical for Resistance against Highly Virulent Aspergillus fumigatus Isolates.

Infection and immunity - 1 Dec 2017

Caffrey-Carr Alayna K, Kowalski Caitlin H, Beattie Sarah R, Blaseg Nathan A, Upshaw Chanell R, Thammahong Arsa, Lust Hannah E, Tang Yi-Wei, Hohl Tobias M, Cramer Robert A, Obar Joshua J

Abstract excerpt

Heterogeneity among Aspergillus fumigatus isolates results in unique virulence potential and inflammatory responses. How these isolates drive specific immune responses and how this affects fungally induced lung damage and disease outcome are unresolved. We demonstrate that the highly virulent CEA10 strain is able to rapidly germinate within the immunocompetent lung environment, inducing greater lung damage,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28947643
DOI: 10.1128/IAI.00661-17
PMCID: PMC5695118

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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