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Article

LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9.

Cancer letters - 1 Dec 2017

Fu Zhiqiang, Chen Changhao, Zhou Quanbo, Wang Yinxue, Zhao Yue, Zhao Xiaohui, Li Wenzhu, Zheng Shangyou, Ye Huilin, Wang Lin, He Zhanghai, Lin Qing, Li Zhihua, Chen Rufu

Abstract excerpt

Our previous study demonstrated that long non-coding RNA (lncRNA) HOTTIP was maximally expressed in PDAC, and promoted cancer cell progression and epithelial to mesenchymal transition (EMT). Numerous studies indicated that lncRNAs or EMT supported cancer stem cells. However, the role of HOTTIP in pancreatic cancer stem cells (PCSCs) remains unclear. Here, we evaluated the role and mechanism of HOTTIP in PCSCs....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28947139
DOI: 10.1016/j.canlet.2017.09.019

Genes

HOXA9
NANOG
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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