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Functional polymorphisms in LncRNA HOTAIR contribute to susceptibility of pancreatic cancer

28 Feb 2019

Abstract excerpt

BACKGROUND: Pancreatic cancer (PC) remains one of the most aggressive cancers worldwide. However, genetic factors underlying PC susceptibility remain largely unclear. Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an oncogene and its genetic variation has been linked to many cancers. However, the associations between genetic variants in HOTAIR gene and PC risk has not yet been reported....

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PMID: 30867650
DOI: 10.1186/s12935-019-0761-x

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