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The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer

11 Mar 2015

Abstract excerpt

BACKGROUND: The human genome encodes many long non-coding RNAs (lncRNAs). However, their biological functions, molecular mechanisms, and the prognostic value associated with pancreatic ductal adenocarcinoma (PDAC) remain to be elucidated. Here, we identify a fundamental role for the lncRNA HOXA transcript at the distal tip (HOTTIP) in the progression and chemoresistance of PDAC. METHODS: High-throughput...

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PMID: 25889214
DOI: 10.1186/s12967-015-0442-z

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The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancerPMID 25889214Read ↗

Ectopic HOTTIP Expression Induces Non-canonical Transactivation Pathways to Promote Growth and Invasiveness in Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

LncRNA HOTTIP modulates cancer stem cell properties in human pancreatic cancer by regulating HOXA9.Semantic proximity Read ↗

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Microarray expression profile analysis of long non-coding RNAs in pancreatic ductal adenocarcinomaSemantic proximity Read ↗

HOTTIP Enhances Gemcitabine and Cisplatin Resistance Through Sponging miR-637 in CholangiocarcinomaSemantic proximity Read ↗

Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal CancersSemantic proximity Read ↗

rs1859168 A > C polymorphism regulates HOTTIP expression and reduces risk of pancreatic cancer in a Chinese population.Semantic proximity Read ↗

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HOTTIP Predicts Poor Survival in Gastric Cancer Patients and Contributes to Cisplatin Resistance by Sponging miR-216a-5pSemantic proximity Read ↗

Long non-coding RNA HOTAIR promotes tumorigenesis and forecasts a poor prognosis in cholangiocarcinomaSemantic proximity Read ↗

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