Article
Prospects of Fine-Mapping Trait-Associated Genomic Regions by Using Summary Statistics from Genome-wide Association Studies.
American journal of human genetics - 5 Oct 2017
Benner Christian, Havulinna Aki S, Järvelin Marjo-Riitta, Salomaa Veikko, Ripatti Samuli, Pirinen Matti
Abstract excerpt
During the past few years, various novel statistical methods have been developed for fine-mapping with the use of summary statistics from genome-wide association studies (GWASs). Although these approaches require information about the linkage disequilibrium (LD) between variants, there has not been a comprehensive evaluation of how estimation of the LD structure from reference genotype panels performs in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.