Article
Clinical impact of KMT2C and SPRY4 expression levels in intensively treated younger adult acute myeloid leukemia patients.
European journal of haematology - 1 Dec 2017
Kayser Sabine, Feszler Maximilian, Krzykalla Julia, Schick Matthias, Kramer Michael, Benner Axel, Thol Felicitas, Platzbecker Uwe, Müller-Tidow Carsten, Ho Anthony D, Ehninger Gerhard, Heuser Michael, Schlenk Richard F, Thiede Christian, Röllig Christoph, Krämer Alwin
Abstract excerpt
OBJECTIVE: To evaluate the prognostic impact of gene expression levels (ELs) of two tumor suppressor genes, sprouty 4 (SPRY4, located on 5q) and lysine methyltransferase 2C (KMT2C, located on 7q) in correlation with clinical characteristics and genetic abnormalities assessed at initial diagnosis in acute myeloid leukemia (AML). METHOD: Gene expression levels were measured on cDNA by RT-qPCR from diagnostic bone...
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