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Clinical impact of the genomic landscape and leukemogenic trajectories in non-intensively treated elderly acute myeloid leukemia patients.

Leukemia - 1 Nov 2023

Jahn Ekaterina, Saadati Maral, Fenaux Pierre, Gobbi Marco, Roboz Gail J, Bullinger Lars, Lutsik Pavlo, Riedel Anna, Plass Christoph, Jahn Nikolaus, Walter Claudia, Holzmann Karlheinz, Hao Yong, Naim Sue, Schreck Nicholas, Krzykalla Julia, Benner Axel, Keer Harold N, Azab Mohammad, Döhner Konstanze, Döhner Hartmut

Abstract excerpt

To characterize the genomic landscape and leukemogenic pathways of older, newly diagnosed, non-intensively treated patients with AML and to study the clinical implications, comprehensive genetics analyses were performed including targeted DNA sequencing of 263 genes in 604 patients treated in a prospective Phase III clinical trial. Leukemic trajectories were delineated using oncogenetic tree modeling and...

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Identifiers

PMID: 37591941
DOI: 10.1038/s41375-023-01999-6
PMCID: PMC10624608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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