Article
Epigenetics meets genetics in acute myeloid leukemia: clinical impact of a novel seven-gene score.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Feb 2014
Marcucci Guido, Yan Pearlly, Maharry Kati, Frankhouser David, Nicolet Deedra, Metzeler Klaus H, Kohlschmidt Jessica, Mrózek Krzysztof, Wu Yue-Zhong, Bucci Donna, Curfman John P, Whitman Susan P, Eisfeld Ann-Kathrin, Mendler Jason H, Schwind Sebastian, Becker Heiko, Bär Constance, Carroll Andrew J, Baer Maria R, Wetzler Meir, Carter Thomas H, Powell Bayard L, Kolitz Jonathan E, Byrd John C, Plass Christoph, Garzon Ramiro, Caligiuri Michael A, Stone Richard M, Volinia Stefano, Bundschuh Ralf, Bloomfield Clara D
Abstract excerpt
PURPOSE: Molecular risk stratification of acute myeloid leukemia (AML) is largely based on genetic markers. However, epigenetic changes, including DNA methylation, deregulate gene expression and may also have prognostic impact. We evaluated the clinical relevance of integrating DNA methylation and genetic information in AML. METHODS: Next-generation sequencing analysis of methylated DNA identified differentially...
Topics
Join the communities discussing this publication.