Article
Clinicopathological and molecular analyses of uterine carcinosarcomas using next-generation sequencing: A single-center experience.
Indian journal of pathology & microbiology - 1 Jan 2000
Erdogan Ezgi Genc, Yalta Tülin D, Can Nuray, Süt Necdet, Taştekin Ebru, Usta Ufuk, Puyan Fulya Öz, Usturalı Keskin Fatma E, Kurt Busem B
Abstract excerpt
Background: Uterine carcinosarcomas (UCS) constitute 3-4% of all uterine malignancies and 16% of deaths caused due to uterine neoplasms. Aim: In this study, we aimed to perform DNA-based mutation analysis in 12 genes (KRAS, NRAS, EGFR, C-KIT, BRAF, PDGFRA, ALK, ERBB2, ERBB3, ESR1, RAF1, PIK3CA) to determine the molecular subtypes of UCS using next-generation sequencing (NGS) in patients with aggressive UCS and...
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