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DNA vaccination protects mice against Zika virus-induced damage to the testes

7 Jun 2017

Abstract excerpt

Zika virus (ZIKV) is an emerging pathogen causally associated with serious sequelae in fetuses, inducing fetal microcephaly and other neurodevelopment defects. ZIKV is primarily transmitted by mosquitoes, but can persist in human semen and sperm, and sexual transmission has been documented. Moreover, exposure of type-I interferon knockout mice to ZIKV results in severe damage to the testes, epididymis and sperm....

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PMID: 28589934
DOI: 10.1038/ncomms15743

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