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Article

Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/β-Catenin and PI3K/Akt Signaling.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2017

Kang Dong Woo, Lee Bo Hui, Suh Young-Ah, Choi Yong-Seok, Jang Se Jin, Kim Yong Man, Choi Kang-Yell, Min Do Sik

Abstract excerpt

Purpose: Dysregulated expression of PLD1 has emerged as a hallmark feature of colorectal cancer, which remains a major cause of mortality worldwide. Aberrant activation of Wnt/β-catenin signaling is a critical event in the development of colorectal cancer. Here, we investigated molecular crosstalk between the Wnt/β-catenin and PI3K/Akt pathways via inhibitor of β-catenin and T-cell factor (ICAT), a negative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28939743
DOI: 10.1158/1078-0432.CCR-17-0749

Genes

PLD1
APC

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Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/β-Catenin and PI3K/Akt Signaling.PMID 28939743Read ↗

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