Article
Clinical Outcomes and Co-Occurring Mutations in Patients with RUNX1-Mutated Acute Myeloid Leukemia.
International journal of molecular sciences - 26 Jul 2017
Khan Maliha, Cortes Jorge, Kadia Tapan, Naqvi Kiran, Brandt Mark, Pierce Sherry, Patel Keyur P, Borthakur Gautam, Ravandi Farhad, Konopleva Marina, Kornblau Steven, Kantarjian Hagop, Bhalla Kapil, DiNardo Courtney D
Abstract excerpt
(1) Runt-related transcription factor 1 (RUNX1) mutations in acute myeloid leukemia (AML) are often associated with worse prognosis. We assessed co-occurring mutations, response to therapy, and clinical outcomes in patients with and without mutant RUNX1 (mRUNX1); (2) We analyzed 328 AML patients, including 177 patients younger than 65 years who received intensive chemotherapy and 151 patients >65 years who...
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