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Article

Effects and mechanism of adenovirus-mediated phosphatase and tension homologue deleted on chromosome ten gene on collagen deposition in rat liver fibrosis.

World journal of gastroenterology - 28 Aug 2017

Xie Shu-Rui, An Jun-Yan, Zheng Li-Bo, Huo Xiao-Xia, Guo Jian, Shih David, Zhang Xiao-Lan

Abstract excerpt

AIM: To evaluate the effects of phosphatase and tension homologue deleted on chromosome ten (PTEN) gene on collagen metabolism in hepatic fibrosis and the underlying mechanisms. METHODS: Rat primary hepatic stellate cells (HSCs) and human LX-2 cells were transfected with adenovirus containing cDNA constructs encoding wild-type PTEN (Ad-PTEN), PTEN mutant G129E gene (Ad-G129E), and RNA interference constructs...

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Identifiers

PMID: 28932082
DOI: 10.3748/wjg.v23.i32.5904
PMCID: PMC5583575

Genes

PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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