Article
A Novel Rat Model of Nonalcoholic Fatty Liver Disease Constructed Through CRISPR/Cas-Based Hydrodynamic Injection.
Molecular biotechnology - 1 Oct 2017
Yu Qin, Tan Rui-Zhi, Gan Quan, Zhong Xia, Wang You-Qiang, Zhou Jing, Wang Li
Abstract excerpt
CRISPR/Cas technology has been widely used in generating conventional and conditional gene knockout animals through germline mutation. A recent study has demonstrated that CRISPR/Cas system also worked on nongermline mutation in mice liver via hydrodynamic injection of vector plasmid to blood circulation. However, whether this is also applied to rat and what is the optimal concentration of vector plasmid still...
Topics
Join the communities discussing this publication.