Article
The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma.
Nature communications - 20 Sept 2017
Mroczek Seweryn, Chlebowska Justyna, Kuliński Tomasz M, Gewartowska Olga, Gruchota Jakub, Cysewski Dominik, Liudkovska Vladyslava, Borsuk Ewa, Nowis Dominika, Dziembowski Andrzej
Abstract excerpt
FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C into multiple myeloma cell lines, but not its catalytically-inactive mutant, leads to broad polyadenylation and...
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