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Article

Structural and Functional Analyses of the FAM46C/Plk4 Complex.

Structure (London, England : 1993) - 4 Aug 2020

Chen Hua, Lu Defen, Shang Guijun, Gao Guoming, Zhang Xuewu

Abstract excerpt

FAM46C, a non-canonical poly(A) polymerase, is frequently mutated in multiple myeloma. Loss of function of FAM46C promotes cell survival of multiple myeloma, suggesting a tumor-suppressive role. FAM46C is also essential for fastening sperm head and flagellum, indispensable for male fertility. The molecular mechanisms of these functions of FAM46C remain elusive. We report the crystal structure of FAM46C to provide...

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Identifiers

PMID: 32433990
DOI: 10.1016/j.str.2020.04.023
PMCID: PMC7415566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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