Article
SRP-dependent co-translational targeting and SecA-dependent translocation analyzed as individual steps in the export of a bacterial protein.
The EMBO journal - 1 Dec 2000
Neumann-Haefelin C, Schäfer U, Müller M, Koch H G
Abstract excerpt
Recently it has been recognized that the signal recognition particle (SRP) of Escherichia coli represents a specific targeting device for hydrophobic inner membrane proteins. It has remained unclear, however, whether the bacterial SRP functions in concert with SecA, which is required for the translocation of secretory proteins across the inner membrane. Here, we have analyzed a hybrid protein constructed by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.