Article
A vascular endothelial growth factor A genetic variant is associated with improved ventricular function and transplant-free survival after surgery for non-syndromic CHD.
Cardiology in the young - 1 Jan 2018
Mavroudis Constantine D, Seung Kim Daniel, Burnham Nancy, Morss Alexandra H, Kim Jerry H, Burt Amber A, Crosslin David R, McDonald-McGinn Donna M, Zackai Elaine H, Cohen Meryl S, Nicolson Susan C, Spray Thomas L, Stanaway Ian B, Nickerson Deborah A, Russell Mark W, Hakonarson Hakon, Jarvik Gail P, Gaynor J William
Abstract excerpt
BACKGROUND: We have previously shown that the minor alleles of vascular endothelial growth factor A (VEGFA) single-nucleotide polymorphism rs833069 and superoxide dismutase 2 (SOD2) single-nucleotide polymorphism rs2758331 are both associated with improved transplant-free survival after surgery for CHD in infants, but the underlying mechanisms are unknown. We hypothesised that one or both of these minor alleles...
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