Validation of association of the apolipoprotein E ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants.

doi:10.1016/j.jtcvs.2014.07.052

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Article

Validation of association of the apolipoprotein E ε2 allele with neurodevelopmental dysfunction after cardiac surgery in neonates and infants.

The Journal of thoracic and cardiovascular surgery - 1 Dec 2014

Gaynor J William, Kim Daniel Seung, Arrington Cammon B, Atz Andrew M, Bellinger David C, Burt Amber A, Ghanayem Nancy S, Jacobs Jeffery P, Lee Teresa M, Lewis Alan B, Mahle William T, Marino Bradley S, Miller Stephen G, Newburger Jane W, Pizarro Christian, Ravishankar Chitra, Santani Avni B, Wilder Nicole S, Jarvik Gail P, Mital Seema, Russell Mark W

Abstract excerpt

OBJECTIVE: Apolipoprotein E (APOE) genotype is a determinant of neurologic recovery after brain ischemia and traumatic brain injury. The APOE ε2 allele has been associated with worse neurodevelopmental (ND) outcome after repair of congenital heart defects (CHD) in infancy. Replication of this finding in an independent cohort is essential to validate the observed genotype-phenotype association. METHODS: The...

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Identifiers

PMID: 25282659
DOI: 10.1016/j.jtcvs.2014.07.052
PMCID: PMC4376113

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APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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