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Article

Diastolic Blood Pressure Alleles Improve Congenital Heart Defect Repair Outcomes.

Circulation research - 1 Apr 2022

Breeyear Joseph H, Keaton Jacob M, Torstenson Eric S, Smith Andrew H, Klarin Derek, Damrauer Scott M, Natarajan Pradeep, Van Driest Sara L, Weiner Jeffrey G, Kannankeril Prince J, Edwards Todd L

Abstract excerpt

BACKGROUND: Congenital heart defects (CHDs) affect 40 000 US births per year, half of which require surgical intervention. Individual differences in surgical outcomes including mortality and complications are not well understood but may be due to genetic variability. We hypothesized that polygenic risk scores (PRSs) for blood pressure in adults are associated with treatments and postsurgical outcomes in children...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35199555
DOI: 10.1161/CIRCRESAHA.121.319842
PMCID: PMC9811841

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