Article
Genotypes of SNPs of key genes regulate susceptibility and drug sensitivity to neovascular AMD in the human population.
BMJ open ophthalmology - 12 Apr 2025
Cui Jinglin, Lu Hang, Wang Suoxi, Li Zhuo, Song Xiande, Xiu Weiwei, Liu Boyang, Li Jiayao, Jin Chaoming, Zhao Anqi, Ding Hongyang, Sun Dawei, Jablonski Monica M, Lu Lu, Gu Weikuan, Yang Baofeng
Abstract excerpt
OBJECTIVE: To compare the genetic characteristics of the normal control group to those of neovascular age-related macular degeneration (AMD) patients and to detect single-nucleotide polymorphisms (SNPs) related to the pathogenesis of neovascular AMD and the sensitivity to anti-VEGF drug, combercept. METHOD: This is a prospective case-controlled study. A total of 104 neovascular AMD patients were treated with...
Read the complete abstract on PubMedTopics
- Humans
- Polymorphism, Single Nucleotide
- Male
- Female
- Aged
- Case-Control Studies